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Efficacy of
Sulforaphane in Eradicating Helicobacter pylori in Human Gastric Xenografts
Implanted in Nude Mice.
Antimicrob Agents Chemother. 2003 Dec;47(12):3982-3984.
Haristoy X, Angioi-Duprez K, Duprez A, Lozniewski A.
Laboratoire de Bacteriologie-Virologie, UMR CNRS 75-65. Laboratoire de
Microchirurgie Experimentale. Laboratoire d'Anatomie Pathologique EMI INSERM
0014,Faculte de Medecine, Universite Henri-Poincare, Vandaeuvre-les-Nancy,
France.
Sulforaphane, an isothiocyanate abundant in the form of its glucosinolate
precursor in broccoli sprouts, has shown in vitro activity against Helicobacter
pylori. We evaluated the effect of sulforaphane in vivo against this bacterium
by using human gastric xenografts in nude mice. H. pylori was completely
eradicated in 8 of the 11 sulforaphane-treated grafts. This result suggests that
sulforaphane might be beneficial in the treatment of H. pylori-infected
individuals.
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